Non-hemolytic streptococci induce the virescence of the blood medium and determined as a-hemolytic streptococci. Group A hemolytic streptococci are responsible for most human streptococcal disease. Streptococcus Bovis is the main human pathogen among non-enterococcal Group D streptococci.
Streptococcus Bovis infection is a well-documented cause of infective endocarditis. Streptococcus Bovis also causes bacteremia without endocarditis and, less frequently, urinary tract infections, meningitis, neonatal sepsis, spontaneous bacterial peritonitis, and, rarely, septic arthritis, vertebral osteomyelitis, and peritonitis associated with continuous ambulatory peritoneal dialysis.