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From High Dilutions to Digital Biology

The idea of water memory was introduced by Jacques Benveniste in the late 1980s and has been a heated topic of debate in the scientific community ever since. The review titled “From high dilutions to digital biology: the physical nature of the biological signal” by Y. Thomas briefly discusses experiments related to digital biology and work she has been a part of. In this post, we explore this interesting review, which gives further insight into the use of electromagnetic signals recorded from biologically active substances and the phenomena observed by Jacques Benveniste and his research team.


Method Used to Produce Signals from a Biologically Active Substance

One hypothesis to explain water memory is that molecules can communicate with each other without being in physical contact and that biological functions may be mimicked by certain energetic modes, which characterize a given molecule and thus biological signaling might be transmissible by electromagnetic means. In the early 1990s, a procedure using an amplifier and electromagnetic coil was successfully developed to transfer specific molecular signals to biological systems and in 1995 a more sophisticated technique was designed, which recorded, digitized, and replayed these signals using a computer (Fig. 1). In essence, the method involved first capturing the electromagnetic signal from a biologically active solution and then storing the digital signal. Next, the signal is amplified and then replayed to cells, organs, or indirectly to water contained in a solenoid coil. 

Fig. 1. Schematic diagram showing a system to produce a characteristic electric signal, designed by J. Benveniste.


Experimental Findings


1. Effect of Acetylcholine and Histamine on Guinea-Pig Hearts

The effect of the digital signals of acetylcholine (a.k.a. acetylcholine IC) and histamine (a.k.a. histamine IC) on isolated guinea-pig hearts was investigated. Normally, acetylcholine and histamine cause vasodilation and consequently, an increase in local blood flow. Through consecutive blind experiments, it was found that not only did the molecules of acetylcholine and histamine cause an increase in coronary flow but so did their ICs. Additionally, comparing acetylcholine IC and histamine IC to water exposed to just background carrier waves (i.e. sham control), showed a significant difference (Fig. 2). Interesting to note, when atropine, a molecule that inhibits the action of acetylcholine was introduced, both the effects of acetylcholine and the acetylcholine IC were inhibited, but not those of histamine or histamine IC. Similarly, when the antihistamine molecule mepyramine was used, the actions of both histamine and histamine IC were inhibited, but not acetylcholine or acetylcholine IC.  

Fig. 2. Effects of digital acetylcholine and histamine on the coronary flow in isolated guinea-pig hearts.


2. Effect of Phorbol-Myristate Acetate on Human Neutrophils

Human neutrophils are a special group of white blood cells that play an extremely important role in protecting the body against infections. In this set of experiments the effect of the digital signal of phorbol-myristate acetate (PMA) – a.k.a. PMA IC – on human neutrophils through the production of reactive oxygen metabolites (ROMs), was investigated. It was found that PMA IC stimulated ROM production, i.e. activates the neutrophils, as PMA molecule itself (Fig. 3). 

Fig. 3. Effects of digital phorbol-myristate-acetate (PMA) on neutrophil ROM production.


3. Effect of Direct Thrombin Inhibitor on Blood Coagulation

Briefly, the mechanism of blood coagulation is highly complex and there are various molecules involved. Two of these molecules are thrombin and fibrinogen, which can interact in water without any other participant normally needed to form a clot. In the last step of the coagulation pathway, thrombin transforms fibrinogen into fibrin monomers that automatically polymerize into a loose mesh, and within a short period a clot forms. When a Direct Thrombin Inhibitor (DTI), such as melagatran, is added, the thrombin-fibrinogen reaction can be delayed or blocked. Knowing this, the authors wanted to see whether the digital signal of DTI (a.k.a. DTI IC) could affect thrombin-induced fibrinogen coagulation. It was found that for the majority of the experiments performed (22 consecutive blind experiments), a delay in blood coagulation was observed when DTI IC was used, and it was significantly different compared to water exposed to just background carrier waves (i.e. sham control) (Fig. 4). However, the delay was to a lesser extent than to what was observed with DTI molecule.

Fig. 4. Effects of digital thrombin inhibitor on thrombin-induced fibrinogen coagulation.


What Do We Learn from This Review?

The findings reviewed by Y. Thomas validate and confirm the original observations made by Benveniste and his team. Although further research is needed to fully understand what is going on, these findings further corroborate the beneficial use of informational medicine, which includes infoceuticals, in future clinical practice.



Thomas, Y. From high dilutions to digital biology: the physical nature of the biological signal. Homeopathy 2015; 104: 295–300.

Post created: Jun 03, 2019, by: Anton Sheikh-Fedorenko 206   1

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